FGFR1

FGFR1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1AGW, 1CVS, 1EVT, 1FGI, 1FGK, 1FQ9, 1XR0, 2CR3, 2FGI, 3C4F, 3DPK, 3GQI, 3GQL, 3JS2, 3KRJ, 3KRL, 3KXX, 3KY2, 3RHX, 3TT0, 4F63, 4F64, 4F65, 4NK9, 4NKA, 4NKS, 4RWI, 4RWJ, 4RWK, 4RWL, 4UWY, 4WUN, 5AM6, 5AM7, 4ZSA, 5A4C, 4UWB, 4UWC, 5A46, 5FLF, 5EW8, 5B7V
Identifikatori
Aliasi	FGFR1
Vanjski ID-jevi	OMIM: 136350 MGI: 95522 HomoloGene: 69065 GeneCards: FGFR1
Lokacija gena (čovjek) Hrom. Hromosom 8 (čovjek)[1] Bend 8p11.23 Početak 38,400,215 bp[1] Kraj 38,468,834 bp[1]
Lokacija gena (miš) Hrom. Hromosom 8 (miš)[2] Bend 8 A2|8 14.12 cM Početak 26,003,670 bp[2] Kraj 26,065,734 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • kinase activity • transmembrane receptor protein tyrosine kinase activity • ATP binding • protein kinase activity • aktivnost sa transferazom • protein homodimerization activity • GO:0001948, GO:0016582 vezivanje za proteine • nucleotide binding • vezivanje identičnih proteina • fibroblast growth factor binding • fibroblast growth factor-activated receptor activity • heparin binding • 1-phosphatidylinositol-3-kinase activity • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • receptor-receptor interaction • Receptorska tirozin-kinaza • transmembrane signaling receptor activity • SH2 domain binding Ćelijska komponenta • citoplazma • citosol • membrana • extracellular region • jedro • receptor complex • integral component of plasma membrane • GO:0016023 citoplazmatska vezikula • ćelijska membrana • integral component of membrane • Jedarce Biološki proces • skeletal system development • ureteric bud development • fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development • positive regulation of endothelial cell chemotaxis to fibroblast growth factor • positive regulation of MAP kinase activity • positive regulation of phospholipase C activity • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling • positive regulation of cardiac muscle cell proliferation • mesenchymal cell differentiation • positive regulation of mesenchymal cell proliferation • Angiogeneza • orbitofrontal cortex development • positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway • branching involved in salivary gland morphogenesis • GO:0009373 regulation of transcription, DNA-templated • blood vessel morphogenesis • regulation of extrinsic apoptotic signaling pathway in absence of ligand • lung development • in utero embryonic development • cell maturation • negative regulation of gene expression • transcription, DNA-templated • positive regulation of cell cycle • embryonic limb morphogenesis • positive regulation of neuron differentiation • protein autophosphorylation • auditory receptor cell development • positive regulation of MAPK cascade • paraxial mesoderm development • chondrocyte differentiation • organ induction • Fosforilacija • ventricular zone neuroblast division • skeletal system morphogenesis • neuron migration • outer ear morphogenesis • GO:1901227 negative regulation of transcription by RNA polymerase II • middle ear morphogenesis • Regulacija ekspresije gena • phosphatidylinositol-mediated signaling • midbrain development • chordate embryonic development • sluh • salivary gland morphogenesis • generation of neurons • MAPK cascade • regulation of lateral mesodermal cell fate specification • positive regulation of phospholipase activity • brain development • regulation of cell population proliferation • inner ear morphogenesis • positive regulation of neuron projection development • regulation of cell differentiation • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • lung-associated mesenchyme development • Ćelijska migracija • phosphatidylinositol-3-phosphate biosynthetic process • phosphatidylinositol phosphate biosynthetic process • protein phosphorylation • fibroblast growth factor receptor signaling pathway • positive regulation of cell population proliferation • positive regulation of parathyroid hormone secretion • negative regulation of fibroblast growth factor production • vitamin D3 metabolic process • regulation of phosphorus metabolic process • positive regulation of mitotic cell cycle DNA replication • positive regulation of protein kinase B signaling • regulation of phosphate transport • positive regulation of blood vessel endothelial cell migration • positive regulation of vascular endothelial cell proliferation • ear development • negative regulation of signal transduction • Ćelijska diferencijacija • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • transmembrane receptor protein tyrosine kinase signaling pathway • nervous system development • positive regulation of cell differentiation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	2260	14182
Ensembl	ENSG00000077782	ENSMUSG00000031565
UniProt	P11362	P16092
RefSeq (mRNK)	NM_001174063 NM_001174064 NM_001174065 NM_001174066 NM_001174067 NM_015850 NM_023105 NM_023106 NM_023107 NM_023108 NM_023109 NM_023110 NM_023111 NM_032191 NM_001354367 NM_001354368 NM_001354369 NM_001354370	NM_001079908 NM_001079909 NM_010206
RefSeq (bjelančevina)	NP_001167534 NP_001167535 NP_001167536 NP_001167537 NP_001167538 NP_056934 NP_075593 NP_075594 NP_075598 NP_001341296 NP_001341297 NP_001341298 NP_001341299	NP_001073377 NP_001073378 NP_034336
Lokacija (UCSC)	Chr 8: 38.4 – 38.47 Mb	Chr 8: 26 – 26.07 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Receptor 1 fibroblastnog faktora rasta (FGFR1), znan i kao receptor 1 osnovnog fibroblastnog faktora rasta, fms-srodna tirozin-kinaza-2/Pfeifferov sindrom i CD331, receptor tirozin-kinaze čiji su ligandi specifični članovi porodice faktora rasta fibroblasta. Pokazalo se da je FGFR1 povezan sa Pfeifferovim sindromom.^[5]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000077782 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000031565 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Itoh N, Terachi T, Ohta M, Seo MK (Jun 1990). "The complete amino acid sequence of the shorter form of human basic fibroblast growth factor receptor deduced from its cDNA". Biochemical and Biophysical Research Communications. 169 (2): 680–5. doi:10.1016/0006-291X(90)90384-Y. PMID 2162671.